Substrate R–X
CH₃–X
1° (CH₃CH₂–X)
2° ((CH₃)₂CH–X)
3° ((CH₃)₃C–X)
Benzylic / allylic
Nucleophile
Strong (OH⁻, CN⁻, I⁻, RS⁻)
Weak (H₂O, ROH)
Solvent
Polar protic (H₂O, EtOH)
Polar aprotic (DMSO, acetone, DMF)
Leaving group
I⁻
Br⁻
Cl⁻
F⁻
Animate